英文名稱 | Tideglusib (Synonyms: NP031112; NP-12) |
---|---|
中文名稱 | 替格魯西布 | 泰格列凈 |
CAS號 | 865854-05-3 |
分子式 | C19H14N2O2S |
分子量 | 334.39 |
外觀 | White to off-white powder |
儲存條件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
英文名稱 | Tideglusib (Synonyms: NP031112; NP-12) |
---|---|
中文名稱 | 替格魯西布 | 泰格列凈 |
CAS號 | 865854-05-3 |
分子式 | C19H14N2O2S |
分子量 | 334.39 |
外觀 | White to off-white powder |
儲存條件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
Tideglusib, also known as NP031112, is a GSK-3 inhibitor, which is currently under clinical trial for Alzheimer's disease. Tideglusib protects neural stem cells against NMDA receptor overactivation. Tideglusib reduces progression of brain atrophy in progressive supranuclear palsy in a randomized trial. Tideglusib prevents inflammation and neurodegeneration under excitotoxic conditions: potential therapeutic role in brain disorders.