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奧當(dāng)卡替

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Odanacatib (Synonyms: MK-0822)

產(chǎn)品編號(hào):CL2555 CAS No.:603139-19-1 MDLNo: 分子式:C25H27F4N3O3S 分子量:525.56
規(guī)格 庫(kù)存 目錄價(jià) 會(huì)員專享價(jià) 數(shù)量
1 mg 3-5days ¥1900.00 登錄后可見(jiàn)
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5 mg 3-5days ¥4180.00 登錄后可見(jiàn)
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基本信息
英文名稱 Odanacatib (Synonyms: MK-0822)
中文名稱奧當(dāng)卡替
CAS號(hào)603139-19-1
分子式C25H27F4N3O3S
分子量525.56
外觀White to brown powder
儲(chǔ)存條件Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
產(chǎn)品詳情

Odanacatib (also known as MK-0822) is a potent, neutral, and selective inhibitor of human/rabbit cathepsin K that may be applied to the management of bone metastases and osteoporosis. With IC50s of 0.2 nM/1 nM, it inhibits cathepsin K (human/rabbit) and shows good selectivity against off-target cathepsins B, L, and S. Odanacatib binds to cathepsin K specifically and inhibits its activity. This may reduce bone resorption, improve bone mineral density, and reverse osteoporotic changes. Approximately 16,000 postmenopausal osteoporosis patients are participating in a phase III trial to assess the potential of odanacatib to reduce fracture risk.
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