英文名稱 | PIK-90 |
---|---|
中文名稱 | N-(7,8-二甲氧基-2,3-二氫咪唑并[1,2-c]喹唑啉-5-基)煙酰胺 |
CAS號(hào) | 677338-12-4 |
分子式 | C18H17N5O3 |
分子量 | 351.36 |
MDL | MFCD12910483 |
外觀 | Off-white to yellow powder |
儲(chǔ)存條件 | Store short-term at 0-4°C or long-term at -20°C in a dry, dark place. |
規(guī)格 | 庫(kù)存 | 目錄價(jià) | 會(huì)員專享價(jià) | 數(shù)量 | |
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英文名稱 | PIK-90 |
---|---|
中文名稱 | N-(7,8-二甲氧基-2,3-二氫咪唑并[1,2-c]喹唑啉-5-基)煙酰胺 |
CAS號(hào) | 677338-12-4 |
分子式 | C18H17N5O3 |
分子量 | 351.36 |
MDL | MFCD12910483 |
外觀 | Off-white to yellow powder |
儲(chǔ)存條件 | Store short-term at 0-4°C or long-term at -20°C in a dry, dark place. |
PIK-90 is recognized as a potent inhibitor of both DNA-PK and PI3K, demonstrating its inhibitory effects on the p110α, p110γ, and DNA-PK with respective IC50 values of 11, 18, and 13 nM. This compound plays a significant role in the realm of molecular biology and cancer research, where its ability to target these key enzymes is of paramount importance.
A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling.
PMID: 16647110 PMCID: PMC2946820 DOI: 10.1016/j.cell.2006.03.035
PMID: 19318683 PMCID: PMC4580965 DOI: 10.1182/blood-2008-06-165068
Dual blockade of lipid and cyclin-dependent kinases induces synthetic lethality in malignant glioma.
PMID: 22802621 PMCID: PMC3411950 DOI: 10.1073/pnas.1202492109